3-Methoxybenzaldehyde → HCID 70591946, compound

HRID 1449007Notes

Reaction equation

HRID 1449007 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH:6]=O.[CH2:11]([O:13][C:14](=[O:23])[CH2:15][C:16]([CH2:18][O:19][C:20](=[O:22])[CH3:21])=O)[CH3:12].[CH2:24]([O:26][C:27](=[O:32])/[CH:28]=[C:29](\[NH2:31])/[CH3:30])[CH3:25]>C(O)C>[CH2:11]([O:13][C:14]([C:15]1[CH:6]([C:5]2[CH:8]=[CH:9][CH:10]=[C:3]([O:2][CH3:1])[CH:4]=2)[C:28]([C:27]([O:26][CH2:24][CH3:25])=[O:32])=[C:29]([CH3:30])[NH:31][C:16]=1[CH2:18][O:19][C:20](=[O:22])[CH3:21])=[O:23])[CH3:12]

Participants

5

Reactant 3

HCID 115693-MethoxybenzaldehydeHCID 6437562-Butenoic acid, 3-amino-, ethyl ester, (2Z)-HCID 11480907Ethyl 4-acetoxyacetoacetate

Product 1

HCID 70591946HCID 70591946, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

After heating a solution of 6.8 g of 3-methoxybenzaldehyde, 9.4 g of γ-acetoxyacetoacetic acid ethyl ester and 6.5 g of β-aminocrotonic acid ethyl ester in 40 ccs of ethanol for 20 hours, the mixture is cooled and the precipitate is filtered off.

Workup

  1. temperaturethe mixture is cooled
  2. filtrationthe precipitate is filtered off

Sources & evidence

ORD record
ord-20a16a0ad6cf45c092c0588bc6445408
Source dataset
uspto-grants-1980_02
Patent number
US04188395

Reaction notes

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