HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 2-Phthalimidomethyl-6-methyl-4-pyridyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 2-Pyridinecarboxaldehyde | HCID 14273 | — |
| Reactant | 2-Butenoic acid, 3-amino-, ethyl ester, (2Z)- | HCID 643756 | — |
| Reactant | Ethyl 4-(1,3-dioxoisoindolin-2-YL)-3-oxobutanoate | HCID 701239 | — |
| Product | 2-Phthalimidomethyl-6-methyl-4-pyridyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester | HCID 70591778 | 75% |
Reaction Steps
A solution of 4.7 ccs of pyridine-2-aldehyde, 12.4 g of phthalimidoacetoacetic acid ethyl ester and 5.85 g of β-aminocrotonic acid ethyl ester in 100 ccs of ethanol is heated under reflux for 24 hours and, after cooling and filtering, crystals (beige) of melting point 156°-158° C. are obtained, yield: 75%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04188395 |
| Source dataset | uspto-grants-1980_02 |
| ORD ID | ord-7a40f5b2a7284e68b6010bd61890c6d8 |
| Source note | uspto-grants-1980_02 |