反应详情

To a solution of 15.9 g of ethyl-β-amino-β-ethoxy acrylate in 30 ml of acetonitrile was added 7.1 g of ethyl isocyanate, and the resulting mixture was allowed to stand at room temperature for one day and one night. The acetonitrile was distilled away under reduced pressure. To the residue was added 100 ml of ether and the system then dried over anhydrous sodium sulfate. The ether was distilled away and the residue was distilled under reduced pressure. Thus, 14 g of ethyl-β-ethylureido-β-ethoxy acrylate of a boiling point of 127° to 130° C. was obtained.

1. distillationThe acetonitrile was distilled away under reduced pressure
2. additionTo the residue was added 100 ml of ether
3. dry with materialthe system then dried over anhydrous sodium sulfate
4. distillationThe ether was distilled away
5. distillationthe residue was distilled under reduced pressure