Isopropylamine → HCID 20350130, compound

HRID 1449144Notes

Reaction equation

HRID 1449144 reaction equation
Cl[C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[N:4]=[CH:5][N:6]2[CH2:11][C:12]1[C:17]([Cl:18])=[CH:16][CH:15]=[CH:14][C:13]=1[Cl:19].[CH:20]([NH2:23])([CH3:22])[CH3:21]>CO>[Cl:19][C:13]1[CH:14]=[CH:15][CH:16]=[C:17]([Cl:18])[C:12]=1[CH2:11][N:6]1[CH:5]=[N:4][C:3]2[C:7]1=[N:8][CH:9]=[N:10][C:2]=2[NH:23][CH:20]([CH3:22])[CH3:21]

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 14416083HCID 14416083, compound

Product 1

HCID 20350130HCID 20350130, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

6-Chloro-9-(2,6-dichlorobenzyl)purine (314 mg), 296 mg of isopropylamine and 25 ml of methanol were treated in the same manner as Example 2 and recrystallized from aqueous ethanol to obtain 276 mg (yield 79%) of 9-(2,6-dichlorobenzyl)-6-isopropylaminopurine as colorless needles melting at 109°-110° C.

Workup

  1. customrecrystallized from aqueous ethanol

Sources & evidence

ORD record
ord-c5ac9e87561e40ad98ee5393028f66e7
Source dataset
uspto-grants-1980_02
Patent number
US04189485

Reaction notes

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