HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Dimethylaminopurine → 9-(2-Chloro-6-fluorobenzyl)-6-dimethylaminopurine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Dimethylaminopurine | HCID 3134 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-Chloro-2-(chloromethyl)-3-fluorobenzene | HCID 108675 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | 9-(2-Chloro-6-fluorobenzyl)-6-dimethylaminopurine | HCID 129802 | 62.2% |
Reaction Steps
In a procedure analogous to that of Example 9, by using 1.63 g of 6-dimethylaminopurine, 1.38 g of potassium carbonate, 50 ml of N,N-dimethylacetamide and 3.58 g of 2-chloro-6-fluorobenzyl chloride, there was obtained 1.9 g of 9-(2-chloro-6-fluorobenzyl)-6-dimethylaminopurine as colorless needles (yield: 62%); m.p. 134°-135° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04189485 |
| Source dataset | uspto-grants-1980_02 |
| ORD ID | ord-93305c4dc0074cdbadbf06a922b3da56 |
| Source note | uspto-grants-1980_02 |