Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trimethoprim | HCID 5578 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethoxyacetyl chloride | HCID 84189 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | HCID 20350284 | HCID 20350284 | — |
Reaction Steps
5.8 g of trimethoprim are suspended in 80 ml of chloroform. After addition of 4 g of triethylamine 2.5 g of ethoxyacetyl chloride are dripped in at room temperature. The mixture is stirred for another hour at 50° C. and then cooled. The triethylammonium chloride is separated by filtration, the filtrate is concentrated and the residue is recrystallized from isopropanol. 4 g of 2-ethoxyacetamido-4-amino-5-(3,4,5-trimethoxybenzyl)-pyrimidine of melting point 175° to 176° C. are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04189581 |
|---|
| Source dataset | uspto-grants-1980_02 |
|---|
| ORD ID | ord-ea874e8756d2492d9d107e3d759be17c |
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| Source note | uspto-grants-1980_02 |
|---|
