7-Aminocephalosporanic acid → HCID 178476912, compound

Participants

Reaction Steps

Reaction of 7-aminocephalosporanic acid with 1-diethoxyphosphinylmethyltetrazole-5-thiol and 1-phosphonomethyltetrazole-5-thiol in the presence of 1 and 3 molecular equivalents of sodium bicarbonate, respectively, as described in Example 10 gives 7β-amino-3-(1-diethoxyphosphinylmethyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid and 7β-amino-3-(1-phosphonomethyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid, respectively.

Provenance & Evidence