Phosphorus tribromide → 1H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)-

HRID 1449195Notes

Reaction equation

HRID 1449195 reaction equation
O[CH2:2][CH2:3][N:4]1[C:8](=[O:9])[C:7]2=[CH:10][CH:11]=[CH:12][CH:13]=[C:6]2[C:5]1=[O:14].P(Br)(Br)[Br:16]>>[Br:16][CH2:2][CH2:3][N:4]1[C:8](=[O:9])[C:7]2=[CH:10][CH:11]=[CH:12][CH:13]=[C:6]2[C:5]1=[O:14]

Participants

3

Reactant 2

HCID 24614Phosphorus tribromideHCID 77499N-(2-Hydroxyethyl)phthalimide

Product 1

HCID 113251H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)-

Procedure

A mixture of 5.35 g (0.028 mol) of N-(2-hydroxyethyl)phthalimide and 7.7 g (0.028 mol) of phosphorus tribromide is warmed until solution is obtained. The reaction mixture is then cooled and poured into ice water. The resulting solid is collected by filtration and washed with water to give N-(2-bromoethyl)phthalimide.

Workup

  1. temperatureis warmed until solution
  2. customis obtained
  3. temperatureThe reaction mixture is then cooled
  4. filtrationThe resulting solid is collected by filtration
  5. washwashed with water

Sources & evidence

ORD record
ord-7146cb54e3124590a5c47315472b6c78
Source dataset
uspto-grants-1980_02
Patent number
US04189573

Reaction notes

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