Benzyl Bromide → HCID 54175266, compound

Participants

Reaction Conditions

Reaction Steps

In 133 g of dimethylformamide (DMF), 22 g of sodium hydride (55%; oil dispersion) was dispersed and the dispersion was cooled to lower than 25° C., and a solution of 133 g of N-(2,6-dichlorophenyl)anthranilaldehyde in 266 g of DMF was added dropwise during 30 minutes to the dispersion and then 85.5 g of benzyl bromide was added dropwise during 30 minutes and the mixture was stirred at 20° C. for 1 hour and 22 g of sodium hydride (55%; oil dispersion) was added and then, 62 g of formaldehyde dimethyl mercaptal S-oxide was added dropwise during 1 hour at the reaction temperature of lower than 25° C. The precipitate was filtered and washed with methanol and water and dried under a reduced pressure to obtain 210.2 g of 1-[N-benzyl-o-(2,6-dichloroanilino)phenyl]2-methylsulfinyl-2-methylthioethylene as pale yellow crystals. Melting point 194° to 196° C. (benzene)

Provenance & Evidence