Sodium Hydroxide → HCID 13023173, compound

Participants

Reaction Conditions

Reaction Steps

In a mixture of 50 ml of ethanol and 30 ml of benzene, 7.0 g (0.017 mole) of ethyl N-benzyl-o-(2,6-dichloroanilino)phenylacetate was dissolved and 31 ml of 2 N-NaOH aq. sol. was added and the mixture was stirred at about 80° C. for 9 hours. The reaction mixture was concentrated under reduced pressure and 70 ml of ether was added to the residue and the reaction product was extracted with 2 N-NaOH aq. sol. The pH of the water phase was adjusted with a dilute hydrochloric acid to 2.0 and the precipitate was extracted with ether and the ether phase was dried over anhydrous sodium sulfate and concentrated under a reduced pressure. The reaction product was recrystallized and 5.1 g of N-benzyl-o-(2,6-dichloroanilino)phenyl acetic acid was obtained as colorless crystals. Yield: 78%

Provenance & Evidence