Ethyl chloroformate → HCID 20349086, compound

Participants

Reaction Steps

1-Methyl-3-(2',4',5'-trichlorophenyl)-3-hydroxyurea (8 g; 0.03 mole) was dissolved in cooled (10° C.) 2 N aqueous sodium hydroxide solution (18 ml.) and mixed with dioxane (80 ml.). Ethyl chloroformate (3.3 ml; 0.034 mole) was added dropwise to the reaction mixture at 10°-15° C. with stirring. The stirring was continued for about 1/2 hour after the addition was completed. The dark, oily product was separated and recrystallized from methanol and boiled with powdered charcoal to yield 2-(2',4',5'-trichlorophenyl)-4-methyl-1,2,4-oxadiazolidine-3,5-dione as tan needle-like crystals melting 112°-114° C. and having the following elemental analysis as calculated for C9H5Cl3N2O3 :

Provenance & Evidence