Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phenylsulphonyl isocyanate → N-[(4-Dimethylamino-6-methylpyrimidin-2-yl)aminocarbonyl]benzenesulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phenylsulphonyl isocyanate | HCID 76096 | — |
| 반응물 | N4,N4,6-trimethylpyrimidine-2,4-diamine | HCID 13729300 | — |
| 용매 | Acetone | HCID 180 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N-[(4-Dimethylamino-6-methylpyrimidin-2-yl)aminocarbonyl]benzenesulfonamide | HCID 23332186 | — |
반응 단계
To a suspension of 15.2 g of 2-amino-4-dimethylamino-6-methylpyrimidine in 400 ml of methylene chloride at ambient temperature was added slowly 18.3 g of benzenesulfonylisocyanate. After stirring for four hours the mixture was stripped in-vacuo and the white semisolid residue triturated with ethyl ether and isolated by filtration. The solid was then slurried in hot acetone, cooled and refiltered to yield the solid named above which decomposed at 180°-182°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04190432 |
| 출처 데이터셋 | uspto-grants-1980_02 |
| ORD ID | ord-87b3baa3551f4220bf81b7b8ae9dccc7 |
| 출처 메모 | uspto-grants-1980_02 |