Benzenesulfonyl isocyanate, 2-chloro- → HCID 23332181, compound

HRID 1449316Notes

Reaction equation

HRID 1449316 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([N:8]([CH3:10])[CH3:9])[CH:5]=[C:4]([O:11][CH3:12])[N:3]=1.[Cl:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[S:20]([N:23]=[C:24]=[O:25])(=[O:22])=[O:21]>C(#N)C>[Cl:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[S:20]([NH:23][C:24]([NH:1][C:2]1[N:7]=[C:6]([N:8]([CH3:9])[CH3:10])[CH:5]=[C:4]([O:11][CH3:12])[N:3]=1)=[O:25])(=[O:22])=[O:21]

Participants

4

Reactant 2

HCID 174071Benzenesulfonyl isocyanate, 2-chloro-HCID 4268692HCID 4268692, compound

Product 1

HCID 23332181HCID 23332181, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To 700 ml of acetonitrile containing 25 g of 2-amino-4-dimethylamino-6-methoxypyrimidine at ambient temperature was added dropwise 32.5 g of 2-chlorobenzenesulfonylisocyanate. The mixture was warmed to 40° and then allowed to stir for five hours at ambient temperature. The solid product named above was isolated by filtration and washed with a small amount of cold ethyl ether. It melted at 224°-226°.

Workup

  1. temperatureThe mixture was warmed to 40°
  2. customabove was isolated by filtration
  3. washwashed with a small amount of cold ethyl ether

Sources & evidence

ORD record
ord-6943aa61b7ae44b0bedeb9d16e84ff7f
Source dataset
uspto-grants-1980_02
Patent number
US04190432

Reaction notes

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