2-Hydroxy-1,2,3-propanetricarboxylic acid hydrate (1:1) → HCID 178513084, compound

Participants

Reaction Steps

Two millimoles of amiloride hydrochloride (604.0 mg) are dissolved in 150 ml of water, with gentle heating and filtered. One millimole of citric acid monohydrate (210.0 mg) is dissolved in 10 ml of water and added to the amiloride solution. The pH of this solution is pH 2.7. `The solution is stored at 5° C. for about 24 hours. The precipitate is washed with 2 ten milliter portions of water and then dried in vacuo at 40° C. After being further dried at 65° C. for 8 hours, the resulting amiloride citrate weighed 330 mg.

Provenance & Evidence