HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,5-Dimethoxytetrahydrofuran → 6-Methoxy-3-nitro-2-(1H-pyrrol-1-yl)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,5-Dimethoxytetrahydrofuran | HCID 79098 | — |
| Reactant | 4-Chloropyridine hydrochloride | HCID 81852 | — |
| Reactant | 2-Amino-6-methoxy-3-nitropyridine | HCID 3852428 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 6-Methoxy-3-nitro-2-(1H-pyrrol-1-yl)pyridine | HCID 10560813 | — |
Reaction Steps
10.45 g (0.0791 mol; 1.2 eq) of 2,5-dimethoxy-tetrahydrofuran and 12.00 g (0.0791 mol; 1.2 eq) of 4chloropyridine hydrochloride are stirred for 10 minutes in 300 cm3 of dioxane. 11.15 g (0.0659 mol) of 2-amino-6methoxy-3-nitropyridine are added and the solution is brought to reflux for 4 h. The dioxane is evaporated under reduced pressure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05599812 |
| Source dataset | uspto-grants-1997_02 |
| ORD ID | ord-d6f43a1b74dc4f1886dc44c48126c3e1 |
| Source note | uspto-grants-1997_02 |