Diethyl Ether → HCID 19978193, compound

Participants

Reaction Steps

In 50 ml of thionylchloride was suspended 6.5 g of 3-isopropyl-6,7-dihydro-5H-thiazolo[3,2-a]pyrimidine-2-carboxylic acid hydrochloride obtained in Example 46, followed by reflux under heating for 1 hour. To the reaction mixture was added dry diethylether. The precipitated crystals were collected by filtration and washed with diethylether to obtain 7.0 g of 3-isopropyl-6,7-dihydro-5H-thiazolo[3,2-a]pyrimidine-2-carbonylchloride hydrochloride. In the mixture 5 ml of pyridine and 5 ml of dimethylformamide was dissolved 500 mg of this compound. To the solution was added 291 mg of 2,5-dimethoxyaniline, followed by stirring at 80uÅ for 12 hours. The solvent was removed under reduced pressure. The residue was crystallized from isopropylalcohol and diethylether. The resulting crystals were recrystallized from isopropylalcohol and saturated hydrogenchloride diethylether solution to obtain 200 mg of the titled compound.

Provenance & Evidence