Hydrochloric Acid → HCID 19978097, compound

Participants

Reaction Conditions

Reaction Steps

To 54.8 mg of N-(3,5-dichlorophenyl)-N-(2-ethoxycarbonylethyl)-3-propyl-6,7-dihydro-5H-thiazolo[3,2-a]-pyrimidine-2-carboxamide hydrochloride obtained in Example 57 was added 5 ml of concentrated hydrochloric acid, followed by stirring at 90° C. for 1 hour. After cooling, the solvent was removed under reduced pressure. The residue was suspended in isopropanol and to the suspension was added diethylether. The formed powder was collected by filtration. This powder was recrystallized from a mixed solvent of methanol and diethylether to obtain 41.9 mg of the titled compound.

Provenance & Evidence