HCID 19978230, compound → HCID 67715152, compound

HRID 1449521Notes

Reaction equation

HRID 1449521 reaction equation
[ClH:1].[CH2:2]([O:4][C:5]([CH2:7][CH2:8][C:9]1[N:13]2[CH2:14][CH2:15][CH2:16][N:17]=[C:12]2[S:11][C:10]=1[C:18]([O:20]C(C)(C)C)=[O:19])=[O:6])[CH3:3]>C(O)C.Cl>[ClH:1].[CH2:2]([O:4][C:5]([CH2:7][CH2:8][C:9]1[N:13]2[CH2:14][CH2:15][CH2:16][N:17]=[C:12]2[S:11][C:10]=1[C:18]([OH:20])=[O:19])=[O:6])[CH3:3]

Participants

3

Reactant 1

HCID 19978230HCID 19978230, compound

Product 1

HCID 67715152HCID 67715152, compoundYield 49.4%

Reagents, catalysts & solvents 1

HCID 21887872Ethanol hydrochlorideSolvent

Procedure

In saturated hydrogenchloride ethanol solution was suspended 13.4 g of tert-butyl 3-(2-ethoxycarbonylethyl)-6,7-dihydro-5H-thiazolo[3,2-a]pyrimidine-2-carboxylate hydrochloride obtained in Example 77, followed by stirring at room temperature for 18 hours. The precipitated crystals were collected by filtration and washed with diethylether to yield 5.63 g of the titled compound.

Workup

  1. filtrationThe precipitated crystals were collected by filtration
  2. washwashed with diethylether

Sources & evidence

ORD record
ord-8a74b0b53ec7497bb0a94c76fe507921
Source dataset
uspto-grants-1997_02
Patent number
US05599813

Reaction notes

Loading…