Triphenylphosphine → HCID 19978109, compound

Participants

Reaction Conditions

Reaction Steps

In 40 ml of tetrahydrofuran was dissolved 916 mg of triphenylphosphin. To the solution was added 550 μl of azodicarboxylic acid diethylester under cooling with ice, followed by cooling to -78° C. To the reaction mixture was added 1.0 g of N-(3,5-dichlorophenyl)-6,7-dihydro-3-hydroxy-5H-thiazolo[3,2-a]pyrimidine-2-carboxamide obtained in Example 111 and 400 μl of hydroxyacetic acid ethylester, followed by raising the reaction temperature to room temperature by the degree. After stirring at room temperature for 1 hour, the solvent was removed under reduced pressure. The residue was purified by silica gel column chromatography (silica gel:50 g) using chloroform and metanol (20:1 by volume) as an eluent to obtain 1.00 g of the titled compound.

Provenance & Evidence