HCID 54124608, compound → HCID 54444748, compound

Participants

Reaction Steps

A solution of 2-tert-butyl-1,1-dioxo-6-propyloxy-1,2-dihydro-1λ6 -benzo[d]isothiazol-3-one (0.346 g, 1.165 mmol) in trifluoroacetic acid (10 mL) was refluxed for 48 hours. NMR of the reaction mixture revealed quantitative deprotection. The mixture was concentrated in vacuo and crystallized from methylene chloride, methanol and hexane, to afford the required product (0.130 g, 46%);

Provenance & Evidence