反应详情

温度

60 °C

To a stirred solution of sodium hydroxide (0.048 g, 1.2 mM) in methanol (4.5 mL) was added 7-iodo-2H-3,1-benzoxazine-2,4(1H)-dione (2.6 g, 9.0 mM). The mixture was heated at 60° C. for 7 hr and the resulting solution was cooled, poured into water and extracted with ethyl acetate. The combined extracts were washed once with dilute sodium hydroxide, dried (MgSO4), filtered and concentrated to leave the title compound (2.0 g, 80%) as a brown oil which slowly crystallized; MS(CI): 278 (M+H).

1. temperaturethe resulting solution was cooled
2. extractionextracted with ethyl acetate
3. washThe combined extracts were washed once with dilute sodium hydroxide
4. dry with materialdried (MgSO4)
5. filtrationfiltered
6. concentrationconcentrated