4-Fluorophenyl isothiocyanate → HCID 53840358, compound

Participants

Reaction Steps

Glycinamide (5.0 g) and 4-fluorophenyl-isothiocyanate (9.18 g) were stirred in chloroform (200 mL). The mixture was heated at reflux for 5 minutes then stirred at ambient temperature for 20 minutes. The precipitated solid was collected by filtration, washed with chloroform and air dried to give 2-[3-(4-fluorophenyl)-thioureido]acetamide (10.7 g) as a light pink solid, m.p. 168°-170° C (dec.). Mass spectrum (EI, M.+) m/z 277. 1H-NMR (DMSO-d6 ; 400 MHz) δ9.97 (broad s, 1H), 7.82 (broad s, 1H), 7.45-7.52 (m, 3H), 7.10-7.17 (m, 3H), and 4.06 ppm (s, 2H).

Provenance & Evidence