HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 2-[3-(5-Fluoro-2-methylphenyl)-thioureido]acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 5-Fluoro-o-tolyl Isothiocyanate | HCID 519443 | — |
| Reactant | Glycinamide hydrochloride | HCID 2723639 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 2-[3-(5-Fluoro-2-methylphenyl)-thioureido]acetamide | HCID 54131961 | 78.8% |
Reaction Steps
A mixture of glycinamide hydrochloride (4.42 g), 5-fluoro-2-methylphenylisothiocyanate (6.68 g), triethyl amine (4.1 g), and chloroform (150 mL) was stirred at ambient temperature for 18 hours. The precipitate was collected by filtration, washed with chloroform and air dried to give 2-[3-(5-Fluoro-2-methylphenyl)-thioureido]acetamide (7.6 g), m.p. 172°-174° C. (dec.). This compound was used without further purification in the next paragraph.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05599829 |
| Source dataset | uspto-grants-1997_02 |
| ORD ID | ord-4ebcb12ba10641d1bef9ec3fcdf9abc5 |
| Source note | uspto-grants-1997_02 |