Triethylamine → 3-(4-Chloro-2-methylphenyl)-2-ethylsulfanyl-3,5-dihydroimidazol-4-one

Participants

Reaction Steps

2-[3-(4-Chloro-2-methylphenyl)-thioureido]-acetamide was prepared by the procedure described in Example 11 using 18.36 g of 4-chloro-2-methylphenylisothiocyanate, 11.05 g of glycinamide hydrochloride, 10.1 g of triethyl amine, and 300 mL of chloroform. 21.4 Grams of the desired compound was obtained, m.p. 170°-172° C. (dec.). Mass spectrum (El, M.+) m/z 257/259. 1H-NMR (DMSO-d6 ; 400 MHz) δ9.38 (s, 1H), 7.62 (broad s, 1H), 7.45 (s, 1H), 7.35 (d, 1H), 7.32 (d, 1H), 7.21 (m, 1H), 7.12 (s, 1H), 4.06 (d, 2H), and 2.17 ppm (s, 3H).

Provenance & Evidence