HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 1-[1,1-Dimethylethoxycarbonyl]-4-[3-(1-methylpropyl)amino-2-pyridinyl]piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Methyl Ethyl Ketone | HCID 6569 | — |
| Reactant | tert-Butyl 4-(3-aminopyridin-2-yl)piperazine-1-carboxylate | HCID 2756375 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-[1,1-Dimethylethoxycarbonyl]-4-[3-(1-methylpropyl)amino-2-pyridinyl]piperazine | HCID 21477632 | — |
Reaction Steps
Following the general procedure of PREPARATION 3 and making non-critical variations but starting with 1-[1,1-dimethylethoxycarbonyl]-4-[(3-amino)-2-pyridinyl)piperazine (International Publication No. WO 88/08424, 1.0 g), 2-butanone (0.27 g) sodium cyanoborohydride (0.23 g), acetic acid (5.1 ml) and methanol, the title compound is obtained, NMR (300 MHz, CDCl3) 7.68, 6.94, 6.86, 4.18, 3.56, 3.33, 3.05, 1.53, 1.47, 1.18 and 0.96 δ.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05599930 |
| Source dataset | uspto-grants-1997_02 |
| ORD ID | ord-3e84e5afe812413c868c73466b00b91e |
| Source note | uspto-grants-1997_02 |