HCID 21477690, compound → HCID 21477641, compound

HRID 1449751Notes

Reaction equation

HRID 1449751 reaction equation
C1(=O)[N:5]([CH2:6][CH2:7][S:8]([NH:11][C:12]2[CH:13]=[C:14]3[C:18](=[CH:19][CH:20]=2)[NH:17][C:16]([C:21]([N:23]2[CH2:28][CH2:27][N:26]([C:29]4[C:34]([NH:35][CH:36]([CH3:38])[CH3:37])=[CH:33][CH:32]=[CH:31][N:30]=4)[CH2:25][CH2:24]2)=[O:22])=[CH:15]3)(=[O:10])=[O:9])C(=O)C2=CC=CC=C12.C1(=O)N(CCS(NC2(C(C3CNCCC3N(C)C3C(NC(C)C)=CC=CN=3)=O)C=C3C(C=CC=C3)=N2)(=O)=O)C(=O)C2=CC=CC=C12>>[NH2:5][CH2:6][CH2:7][S:8]([NH:11][C:12]1[CH:13]=[C:14]2[C:18](=[CH:19][CH:20]=1)[NH:17][C:16]([C:21]([N:23]1[CH2:24][CH2:25][N:26]([C:29]3[C:34]([NH:35][CH:36]([CH3:38])[CH3:37])=[CH:33][CH:32]=[CH:31][N:30]=3)[CH2:27][CH2:28]1)=[O:22])=[CH:15]2)(=[O:9])=[O:10]

Participants

3

Reactant 2

HCID 21477690HCID 21477690, compoundHCID 86750277HCID 86750277, compound

Product 1

HCID 21477641HCID 21477641, compound

Procedure

Following the general procedure of EXAMPLE 32, and making non-critical variations but substituting 1-[5-(2-phthalimidoethanesulfonamido)indole-2-carbonyl]-4-[3-(1-methylethylamino)-2-pyridinyl]piperazine (EXAMPLE 33, 605 mg) for 1-[5-(2-(phthalimidoethanesulfonamido)indole -2-carbonyl]-4-[N -methyl-N-(3-(1-methylethylamino)-2pyridinyl)amino]-piperidine, the title compound is obtained, NMR (CDCl3) 10.62, 7.68, 7.55, 7.25, 7.07, 6.93, 6.84, 6.69, 4.20, 4.04, 3.90-3.50, 3.14 and 1.25 δ.

Sources & evidence

ORD record
ord-42ce2eafe0974ff29dd0539db9933618
Source dataset
uspto-grants-1997_02
Patent number
US05599930

Reaction notes

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