L-Isoleucine, ethyl ester → N-(12-Methoxy-1-oxododecyl)-L-isoleucine, Ethyl ester

Participants

Reaction Steps

The title compound was prepared by the method of Example 14 using the title product of Example 44 (1.1 g, 4 mmol) instead of benzylamine. Chromatography of the crude residue on silica gel using 50--50 ethyl acetate-heptane as eluant gave the title compound (875 mg) as a white powder, m.p. 36.4°-38.1° C. (DSC). The structure was supported by NMR, infrared spectroscopy, optical rotation ([α]36525 +81.9°, CHCl3), elemental analysis, and mass spectroscopy.

Provenance & Evidence