Ethyl (3R)-5-[(tert-butoxycarbonyl)amino]-3-hydroxypentanoate → HCID 53693500, compound

HRID 1449776Notes

Reaction equation

HRID 1449776 reaction equation
[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][C@@H:11]([OH:18])[CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])=[O:7])([CH3:4])([CH3:3])[CH3:2].C(OC(NCC[C@@H:32](O)[CH2:33][C:34]([O:36][CH2:37][CH3:38])=O)=O)C1C=CC=CC=1>>[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][C@@H:11]([O:18][CH:34]1[CH2:33][CH2:32][CH2:38][CH2:37][O:36]1)[CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])=[O:7])([CH3:3])([CH3:4])[CH3:2]

Participants

3

Reactant 2

HCID 27281759Ethyl (3R)-5-[(tert-butoxycarbonyl)amino]-3-hydroxypentanoateHCID 53841312HCID 53841312, compound

Product 1

HCID 53693500HCID 53693500, compoundYield 75%

Procedure

The intended compound (2-b) was prepared in a yield of 75% by a method similar to the process A in EXAMPLE 2, except that ethyl (3R)-5-tert-butoxycarbonylamino-3-hydroxypentanoate (2-a), obtained by the above process B, was used instead of ethyl (3R)-5-benzyloxycarbonylamino-3-hydroxypentanoate (2-a).

Sources & evidence

ORD record
ord-aaff080cdf97480a9dda7ba6856e12db
Source dataset
uspto-grants-1997_02
Patent number
US05599954

Reaction notes

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