(+-)-3-Phenyllactic acid → 2-Acetoxy-3-phenylpropanoic acid

HRID 1449778노트

반응식

HRID 1449778 반응식
[C:1](Cl)(=[O:3])[CH3:2].[OH:5][CH:6]([CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:7]([OH:9])=[O:8]>>[C:1]([O:5][CH:6]([CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:7]([OH:9])=[O:8])(=[O:3])[CH3:2]

참가 물질

3

반응물 2

HCID 3848(+-)-3-Phenyllactic acidHCID 6367Acetyl chloride

생성물 1

HCID 111065762-Acetoxy-3-phenylpropanoic acid수율 100.4%

실험 절차

4.83 g (61.53 mmol) of acetyl chloride are added to 8.88 g (53.49 mmol) of (RS)-2-hydroxy-3-phenyl propanoic acid. The mixture is refluxed for 30 minutes. The excess acetyl chloride is evaporated. 11.18 g of (RS)-2-acetyloxy-3-phenyl propanoic acid are obtained.

후처리

  1. temperatureThe mixture is refluxed for 30 minutes
  2. customThe excess acetyl chloride is evaporated

출처 및 근거

ORD 기록
ord-892abb729d8440acad2efe46be2c240a
출처 데이터셋
uspto-grants-1997_02
특허 번호
US05599951

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