反应详情

In one embodiment the trans-1-amino-2-hydroxycyclopentane may be trans-1-amino-2-indanol. If the trans-1-amino-2-hydroxycyclopentane is trans-(1S,2S)-1-amino-2-indanol, it is converted to cis-(1S,2R)-1-amino-2-indanol; if the trans-1-amino-2-hydroxycyclopentane is trans-(1R,2R)-1-amino-2-indanol, it is converted to cis-(1R,2S)-1-amino-2-indanol. When the amino alkanol is partially resolved trans-1-amino-2-indanol and the amide is a benzamide or acetamide, an additional step of recrystallizing the benzamide or acetamide produces substantially optically pure trans-1-benzamido-2-indanol or trans-1-acetamido-2-indanol.

1. customan additional step of recrystallizing the benzamide or acetamide