HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1449855Generated: November 2, 2026
Sodium Chloride → (E)-N-(2-(fluoromethylene)-4-(p-fluorophenyl)butyl)-N-formyl formamide
https://huagongshe.com/reaction/1449855
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Chloride | HCID 5234 | — |
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | (E)-1-chloro-2-(fluoromethylene)-4-(p-fluorophenyl)butane | HCID 9815806 | — |
| Reactant | Sodium Diformylamide | HCID 10877056 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (E)-N-(2-(fluoromethylene)-4-(p-fluorophenyl)butyl)-N-formyl formamide | HCID 15342055 | — |
Reaction Steps
Combine sodium diformylamide (70 lb) and acetonitrile (903 lb). With agitation, add N,N-dimethylformamide (119 lb). Add a solution of (E)-1-chloro-2-(fluoromethylene)-4-(p-fluorophenyl)butane (126 lb) in toluene. Warm to 80° C. After 6 hours, add a 10% by weight solution of sodium chloride in water (1168 lb). Agitate for 15 minutes, separate the layers. Remove the organic layer to give the title compound as a solution in acetonitrile/N,N-dimethylformamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05599986 |
|---|
| Source dataset | uspto-grants-1997_02 |
|---|
| ORD ID | ord-73fdb5f652bb47e49c7344d800ba6cbc |
|---|
| Source note | uspto-grants-1997_02 |
|---|
