Isopropanol → 4-[3-[4-(6-Fluoro1,2-benzisoxazol-3-yl)-piperidinyl]-2-hydroxy-1-propoxy]phenyl methyl ether

Participants

Role	Name	HCID	Charge
Reactant	Isopropanol	HCID 3776	—
Reactant	3-(4-Piperidyl)-6-fluoro-1,2-benzisoxazole	HCID 849421	—
Reactant	2,3-Epoxypropyl4-methoxyphenyl ether	HCID 19964422	—
Product	4-[3-[4-(6-Fluoro1,2-benzisoxazol-3-yl)-piperidinyl]-2-hydroxy-1-propoxy]phenyl methyl ether	HCID 18467257	—

Reaction Steps

A mixture of 4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidine (4.4 g, 20 mmol) and 2,3-epoxypropyl-4-methoxyphenyl ether (3.7 g, 20.5 mmol) in isopropyl alcohol (80 ml) was heated to reflux for 2 hours. The mixture was cooled and the crystals were collected to yield 6.81 g (85%), m.p.=134°-135° C. ANALYSIS: Calculated for C22H25FN2O4 : 65.99%C 6.29%H 7.00%N Found: 66.11%C 6.31%H 6.84%N

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05599821
Source dataset	uspto-grants-1997_02
ORD ID	ord-9392878333ef496db22982ab32e9d51b
Source note	uspto-grants-1997_02