Fumaric Acid → 2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]1-(2,3-dihydro-1H-isoindol-2-yl)ethanone fumarate

Participants

Role	Name	HCID	Charge
Reactant	Fumaric Acid	HCID 444972	—
Reactant	2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]-1-(2,3-dihydro-1H-isoindol-2-yl)ethanone	HCID 15285696	—
Solvent	Ethanol	HCID 702	—
Product	2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]1-(2,3-dihydro-1H-isoindol-2-yl)ethanone fumarate	HCID 18467344	—

Reaction Steps

Free base (1 g, Example 243B) of 2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]-1-(2,3-dihydro-1H-isoindol-2-yl)ethanone dissolved in hot ethanol (~10 ml) was treated with a solution of fumaric acid (306 mg) in hot ethanol. The mixture was cooled and the product collected, 1.2 gm, m.p. 223°-225° C. ANALYSIS: Calculated for C22H22FN3O2.C4H4O4 : 63.02%C 5.29%H 8.48%N Found: 62.86%C 5.03%H 8.39%N

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05599821
Source dataset	uspto-grants-1997_02
ORD ID	ord-0cb451c219f947b18f17a606682d6357
Source note	uspto-grants-1997_02