Acetic Anhydride → 4-(Acetyloxy)-2-butanone

HRID 1450020Notes

Reaction equation

HRID 1450020 reaction equation
[OH:1][CH2:2][CH2:3][C:4](=[O:6])[CH3:5].[C:7](OC(=O)C)(=[O:9])[CH3:8]>C(O)(=O)C>[C:7]([O:1][CH2:2][CH2:3][C:4](=[O:6])[CH3:5])(=[O:9])[CH3:8]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 1115094-Hydroxy-2-Butanone

Product 1

HCID 1391004-(Acetyloxy)-2-butanone

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Crude 4-acetoxy-2-butanone was prepared as follows. A mixture of 4-hydroxy-2-butanone (101.48 g) and acetic anhydride (131.05 g) was stirred and heated to about 120° C. for about 40 minutes before the acetic acid by-product was removed by vacuum distillation at about 24 torr and vapor temperatures rising to about 49° C. The distillation residue was about 129.0 g of crude 4-acetoxy-2-butanone.

Workup

  1. customwas removed by vacuum distillation at about 24 torr and vapor temperatures
  2. customrising to about 49° C

Sources & evidence

ORD record
ord-c68dbd496e364f19af9a00cbef4652a0
Source dataset
uspto-grants-1997_02
Patent number
US05600009

Reaction notes

Loading…