HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → 3-Bromo-4-chloro-5-fluoro-2-picoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 4-Chloro-5-fluoro-2-methylpyridine | HCID 19691410 | — |
| Product | 3-Bromo-4-chloro-5-fluoro-2-picoline | HCID 19691436 | — |
Reaction Steps
4-Chloro-5-fluoro-2-picoline, the product of Example 66, is treated with bromine in fuming sulfuric acid containing 65% sulfur trioxide for 7 hours at 80° C. as described by L. van der Does and H. J. Hertog in Rec Trav Chim 81:864 (1965) to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05599816 |
| Source dataset | uspto-grants-1997_02 |
| ORD ID | ord-50b7ea4af53a4eae90f99f37b3400dbd |
| Source note | uspto-grants-1997_02 |