1-Benzyl-3-(trifluoromethyl)pyrrolidine-3-carboxylic acid → (1-Benzyl-3-trifluoromethyl-pyrrolidin-3-YL)-methanol

Participants

Reaction Steps

The compound from step 456a (2.32 g) was dissolved in 60 mL of dry THF, 1.12 eq of LAH (1N in dry THF) was added, and the reaction was stirred under N2 for 3 hours. The reaction was quenched by the sequential dropwise addition of 0.35 mL water, 0.35 mL of 15% NaOH and 1.3 mL of water, then the mixture was stirred for 1 hour and filtered. The filtrate was dried and concentrated to give 2.2 g of the title compound.

Provenance & Evidence