HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Bromide → 2,5-Dibenzyl-4,6-dioxooctahydropyrrolo[3,4-c]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Benzyl-4,6-dioxooctahydropyrrolo[3.4-c]pyridine | HCID 19691221 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2,5-Dibenzyl-4,6-dioxooctahydropyrrolo[3,4-c]pyridine | HCID 19691349 | 111.4% |
Reaction Steps
To a mixture of 905 mg of K2CO3 and 400 mg of the compound from step 457b in 5 mL of DMF was added 308 mg of benzyl bromide, and the reaction mixture was stirred at room temperature under N2 for 6.5 hours. The mixture was diluted with ethyl acetate, which was washed With water and brine, dried and concentrated to give 610 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05599816 |
| Source dataset | uspto-grants-1997_02 |
| ORD ID | ord-28b647207d004655ac5f24cc6638723e |
| Source note | uspto-grants-1997_02 |