HCID 67646998, compound → 3-(1-(BOC-amino)-1-cyclopropyl-methyl)pyrrolidine

HRID 1450099Notes

Reaction equation

HRID 1450099 reaction equation
[C:1]([NH:8][CH:9]([CH:13]1[CH2:17][CH2:16][N:15](CC2C=CC=CC=2)[CH2:14]1)[CH:10]1[CH2:12][CH2:11]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]>CO.[Pd]>[C:1]([NH:8][CH:9]([CH:13]1[CH2:17][CH2:16][NH:15][CH2:14]1)[CH:10]1[CH2:11][CH2:12]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]

Participants

4

Reactant 1

HCID 67646998HCID 67646998, compound

Product 1

HCID 196914723-(1-(BOC-amino)-1-cyclopropyl-methyl)pyrrolidineYield 35.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A sample (548 mg) of the compound from step 470d was dissolved in methanol, 140 mg of 10% Pd/C was added, and the mixture was hydrogenated at 4 arm H2 for 42 hours at room temperature. The solution was filtered, and the solvent was removed to give 140 mg of the title compound.

Workup

  1. filtrationThe solution was filtered
  2. customthe solvent was removed

Sources & evidence

ORD record
ord-1c5f3cedde6f49e5b85f80ea76afab0a
Source dataset
uspto-grants-1997_02
Patent number
US05599816

Reaction notes

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