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HRID1450180

反应详情

EQUATION

反应方程式

HRID 1450180 的结构方程式

REACTANTS

反应物

3
结构：CCOC(=O)Cl
HCID10928

Ethyl chloroformate

C3H5ClO2

结构：CC(C)(C)OC(=O)N[C@H](CC1CCCCC1)C(=O)O
HCID2755927

N-(tert-Butoxycarbonyl)-3-cyclohexyl-D-alanine

C14H25NO4

结构：CCOC(=O)N[C@H](CC1CCCCC1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C=O)CCCNC(=N)N.Cl.O
HCID178473527

未命名化合物

PRODUCTS

生成物

1
结构：CCOC(=O)N[C@H](CC1CCCCC1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C=O)CCCNC(=N)N.Cl
HCID178473526

未命名化合物

PROCEDURE

实验过程

By methods substantially equivalent to those described in Examples 1-A, 1-B, 7-A, 1-D, 1-H and 1-I, using ethyl chloroformate in place of MeSO2Cl and using Boc-D-Cha-OH in place of Boc-D-Phe-OH, 0.6 g of EtOCO-D-Cha-Pro-Arg-H.HCl hydrate was prepared. EtOCO-D-Cha-Pro-Arg-H.HCl was purified by RPHPLC (95/5 (A/B) ramp to 60/40 (A/B), 240 min).

WORKUP

后处理

  1. customwas prepared
  2. customEtOCO-D-Cha-Pro-Arg-H.HCl was purified by RPHPLC (95/5 (A/B) ramp to 60/40 (A/B), 240 min)