HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → Ethyl (6-methoxy-1h-indol-3-yl)(oxo)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 6-Methoxy-1H-indole | HCID 76659 | — |
| Product | Ethyl (6-methoxy-1h-indol-3-yl)(oxo)acetate | HCID 19958885 | 68% |
Reaction Steps
7.5 cm3 of oxalyl chloride are added dropwise, under argon and over a period of 30 minutes, to a solution of 8.3 g of 6-methoxyindole, prepared in accordance with the process described by P. L. Feldman and H. Rapoport, Synthesis, (1986), 736, in 100 cm3 of anhydrous diethyl ether. After stirring for two hours, the precipitate formed is separated by filtration and then suspended in 200 cm3 of ethanol. After stirring for ten hours, the product is filtered off with suction and rinsed with diethyl ether. Yield:68% Melting point: 207°-208° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05602131 |
| Source dataset | uspto-grants-1997_02 |
| ORD ID | ord-09651bc09c42452ba22434233af1cc32 |
| Source note | uspto-grants-1997_02 |