Hydroxide → HCID 86750312, compound

Participants

Reaction Steps

A mixture of ethyl 5-(3-formyl-4-nitrophenoxy)pentanoate (0.60 mol) and (4,5-di-hydro-2-hydroxy-5-oxo-1H-pyrrol-3-yl)triphenylphosphonium, hydroxide, inner salt (0.57 mol) in ethanol (1500 ml) was stirred and refluxed for 1 hour. The solvent was removed. The residue was stirred in methylbenzene. The resulting precipitate was filtered off, washed with methylbenzene, 2,2'-oxybispropane and dried, yielding 137.3 g (61%) of (E)-ethyl 5-[3-[(2,5-dioxo-3-pyrrolidinylidene)methyl]-4-nitrophenoxy]pentanoate; mp. 112.4° C. (interm. 1).

Provenance & Evidence