反应详情

17.4 g of tetra-butylammonium tribromide are added, at room temperature, to 7 g of 1-(2,4-dichlorophenyl)-1-propanone dissolved in a mixture of 420 ml of methylene chloride and 140 mi of methanol. After 24 hours, the reaction medium is evaporated to dryness under vacuum. The residue is taken up in water and extracted with ethyl acetate, and the organic phase is dried over sodium sulphate. The solvent is evaporated off under vacuum and the product is then purified on a column of silica, using a mixture of cyclohexane and ethyl acetate (20:1 v/v) as eluent.

1. customthe reaction medium is evaporated to dryness under vacuum
2. extractionextracted with ethyl acetate
3. dry with materialthe organic phase is dried over sodium sulphate
4. customThe solvent is evaporated off under vacuum
5. customthe product is then purified on a column of silica
6. additiona mixture of cyclohexane and ethyl acetate (20:1 v/v) as eluent