HCID 54737697, compound → HCID 54732872, compound

HRID 1450269Notes

Reaction equation

HRID 1450269 reaction equation
[Cl:1][C:2]1[S:28][C:5]2[NH:6][C:7](=[O:27])[C:8]([C:11]3[CH:16]=[CH:15][CH:14]=[C:13]([O:17][C:18]4[CH:23]=[CH:22][CH:21]=[C:20]([N+:24]([O-])=O)[CH:19]=4)[CH:12]=3)=[C:9]([OH:10])[C:4]=2[C:3]=1[CH3:29].[H][H]>C(O)C.[Pt]=O>[Cl:1][C:2]1[S:28][C:5]2[NH:6][C:7](=[O:27])[C:8]([C:11]3[CH:16]=[CH:15][CH:14]=[C:13]([O:17][C:18]4[CH:23]=[CH:22][CH:21]=[C:20]([NH2:24])[CH:19]=4)[CH:12]=3)=[C:9]([OH:10])[C:4]=2[C:3]=1[CH3:29]

Participants

5

Reactant 2

HCID 54737697HCID 54737697, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 54732872HCID 54732872, compound

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 702EthanolSolvent

Procedure

20 mg of platinum oxide are added to a solution of 4.28 g of 2-chloro-3-methyl-4-hydroxy-5-(3-m-nitro-phenoxyphenyl)-6,7-dihydrothieno[2,3-b]pyridin-6-one in 50 ml of 95% ethanol. Hydrogen is passed through the solution until three molar equivalents have been absorbed. The platinum is filtered off and the alcohol is distilled off. 2-Chloro-3-methyl-4-hydroxy-5-(3-m-aminophenoxyphenyl)-6,7-dihydrothieno[2,3-b]pyridin-6-one is obtained.

Workup

  1. customhave been absorbed
  2. filtrationThe platinum is filtered off
  3. distillationthe alcohol is distilled off

Sources & evidence

ORD record
ord-c497b2993e014240bc7473e4ebda0dfc
Source dataset
uspto-grants-1997_02
Patent number
US05602144

Reaction notes

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