Pyridinium chloride → Thieno[2,3-b]pyridin-6(7H)-one

HRID 1450270Notes

Reaction equation

Cl[C:2]1[S:28][C:5]2[NH:6][C:7](=[O:27])[C:8](C3C=CC=C(C(=O)C4C=CC(OC)=CC=4)C=3)=[C:9](O)[C:4]=2[C:3]=1C.Cl.N1C=CC=CC=1>>[S:28]1[C:5]2[NH:6][C:7](=[O:27])[CH:8]=[CH:9][C:4]=2[CH:3]=[CH:2]1

Participants

Reactant 2

HCID 10176127Pyridinium chloride

HCID 54728722HCID 54728722, compound

Product 1

HCID 12325030Thieno[2,3-b]pyridin-6(7H)-one

Procedure

A mixture of 4.25 g of 2-chloro-3-methyl-4-hydroxy-5-(3-p-methoxybenzoylphenyl)-6,7-dihydrothieno [2,3-b]pyridin-6-one and 3.5 g of pyridine hydrochloride is stirred at 160° for 3 hours. 2-Chloro-3-methyl-4-hydroxy-5-3-p-hydroxybenzoylphenyl)-6,7-dihydrothieno [2,3-b]pyridin-6-one is obtained after the customary working-up.

Sources & evidence

ORD record: ord-7094d783f6fc46c28aa34aa693a609b9
Source dataset: uspto-grants-1997_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05602144

Reaction notes

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