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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1450292Generated: October 27, 2026

3-Methyloxazolidine-2,5-dione → 6-(1-Hydroxyethyl)-4-methyl-7-oxo-3-[[tetrahydro-5-[[[(methylamino)acetyl]amino]methyl]-3-furanyl]thio]-1-azabicyclo[3.2.0]hept-3-ene-2-carboxylic acid

https://huagongshe.com/reaction/1450292

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Methyloxazolidine-2,5-dioneHCID 138603—
Reactant3-[[5-(Aminomethyl)tetrahydro-3-furanyl]thio]-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acidHCID 74971528—
SolventTrisodium PhosphateHCID 24243—
Solvent1,4-DioxaneHCID 31275—
Product6-(1-Hydroxyethyl)-4-methyl-7-oxo-3-[[tetrahydro-5-[[[(methylamino)acetyl]amino]methyl]-3-furanyl]thio]-1-azabicyclo[3.2.0]hept-3-ene-2-carboxylic acidHCID 86750325—

Reaction Steps

The title compound is prepared by the procedure of Example 47 using 0.068 g of product from Example 46 in 2.0 ml of sodium phosphate buffer (pH 8.5) and 0. 029 g of 3-methyl -2,5-oxazolidinedione, prepared by the procedure described in J. Org. Chem., 34, No. 1, 243(1969), in 1 ml of dioxane to give 0.036 g of the desired product.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05602118
Source datasetuspto-grants-1997_02
ORD IDord-6b2f138559be4bc7b00b986e79b1f318
Source noteuspto-grants-1997_02