反应详情

To a mixture of 4.32 g of p-nitrobenzyl glyoxalate and 2.0 ml of dimethylphosphite in 25 ml of benzene is added a catalytic amount of p-toluenesulfonic acid. The reaction is heated at reflux temperature for 1.5 hours. The formed water is removed using a Dean-Stark trap. After cooling, the solvent is removed in vacuo and the resulting crystals are slurried in ethyl acetate and collected to give 3.48 g of the desired product.

1. temperatureThe reaction is heated
2. temperatureat reflux temperature for 1.5 hours
3. customThe formed water is removed
4. temperatureAfter cooling
5. customthe solvent is removed in vacuo
6. customcollected