反应详情

温度

0 °C

To a -78° C. solution, under argon, of 4.23 g of product from Example 175 in 28 ml of dry methylene chloride is added, dropwise, 17.2 ml of 1M boron trichloride. The reaction mixture is warmed to 0° C. and stirred for 1 hour. The reaction is quenched with methyl alcohol, concentrated in vacuo and chromatographed (silica gel: 0-30% ethyl acetate/hexane) to give 2.57 g of the desired product (1:1 mixture of isomers).

1. customThe reaction is quenched with methyl alcohol
2. concentrationconcentrated in vacuo
3. customchromatographed (silica gel: 0-30% ethyl acetate/hexane)