Phosphorus pentachloride → HCID 18919386, compound

HRID 1450367Notes

Reaction equation

HRID 1450367 reaction equation
[C:1]([N:4]([C:20](=[O:22])[CH3:21])[C:5]1[C:10]([CH:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[CH:9][CH:8]=[CH:7][C:6]=1[S:16](O)(=[O:18])=[O:17])(=[O:3])[CH3:2].P(Cl)(Cl)(Cl)(Cl)[Cl:24]>ClCCl>[C:1]([N:4]([C:20](=[O:22])[CH3:21])[C:5]1[C:10]([CH:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[CH:9][CH:8]=[CH:7][C:6]=1[S:16]([Cl:24])(=[O:18])=[O:17])(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 24819Phosphorus pentachlorideHCID 18919378HCID 18919378, compound

Product 1

HCID 18919386HCID 18919386, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 1.55 g (3.6 mmol) of 2-(diacetylamino)-3-cyclopentylbenzenesulphonic acid and 1.12 g (5.4 mmol) of phosphorus pentachloride in 10 ml of dichloromethane is heated at the reflux temperature for 2.5 hours, and the reaction medium is then concentrated under reduced pressure. The residue thus obtained is purified by chromatography on a column of florisil™, eluting with dichloromethane.

Workup

  1. concentrationthe reaction medium is then concentrated under reduced pressure
  2. customThe residue thus obtained
  3. customis purified by chromatography on a column of florisil™
  4. washeluting with dichloromethane

Sources & evidence

ORD record
ord-57cf515f10fe497ca7dcccf28f182fa7
Source dataset
uspto-grants-1997_02
Patent number
US05602149

Reaction notes

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