HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,7-Dichloro-5-ethylpyrazolo[1,5-a]pyrimidine → 3-Chloro-7-[N-(2'-cyanobiphenyl-4-yl)methyl-N-methylamino]-5-ethylpyrazolo[1,5-a]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,7-Dichloro-5-ethylpyrazolo[1,5-a]pyrimidine | HCID 10632484 | — |
| Reactant | N-(2'-Cyanobiphenyl-4-yl)methyl-N-methyl amine | HCID 15337416 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-Chloro-7-[N-(2'-cyanobiphenyl-4-yl)methyl-N-methylamino]-5-ethylpyrazolo[1,5-a]pyrimidine | HCID 19975994 | — |
Reaction Steps
3.1 g (14.4 mmol) of the chloro compound (Example 3, Step A) and 3.2 g (14.4 mmol) of the amine (Example 1, Step C) were heated in 75 ml ethanol according to Example 4, Step C. The title compound was obtained as an oil after chromatography (silica gel; dichloromethane with ascending polarity by addition of up to 3% ethanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05602137 |
| Source dataset | uspto-grants-1997_02 |
| ORD ID | ord-9ded4c1964454b48b581479d0c95262c |
| Source note | uspto-grants-1997_02 |