Sodium Carbonate → HCID 19975803, compound

Participants

Reaction Steps

1.8 g (9.9 mmol) 7-Chloro-5-ethylpyrazolo[l,5-a]pyrimidine (Example 1, Step B) and 1.4 g (10.0 mmol) ethyl 2-aminoacetate hydrochloride were dissolved in 50 ml dry ethanol. 500 mg (4.7 mmol) sodium carbonate were added, and the mixture was heated with reflux for 2 h. The inorganic material was filtered off, the residue treated with saturated aqueous sodium bicarbonate solution, and extracted with ethyl acetate. The organic layer was dried over sodium sulfate, and evaporated in vacuo to give the crude title compound as an oil, which was pure enough according to its 1H-NMR spectrum and was used for the reaction of the next step without further purification.

Provenance & Evidence